Some Of The Best Anime Groups Of 4 With GREAT Chemistry

Usually an anime series on average will have one or two main characters. It’s easier that way as far as focus.

Sometimes though there’s multiple main characters. As much as 3, 4, or in rare cases 5.

This time around let’s focus on anime groups of 4 from various anime shows in different genres.

Let’s get into it.

Best anime with groups of 4:

1. Black Lagoon

You have

Revy Rebecca.
Rock.
Benny.
Dutch.

Literally the 4 main characters of this action series.

The plot is about smuggling (weapons, etc). Dutch is the leader of the lagoon company.

The chemistry between these 4 characters is always a good laugh and there’s plenty to get out of it. Entertainment wise.

All 4 characters aren’t always side by side, but giving they work within the same company it’s a lot of the time as they travel around the world. Doing “dirty” business.

It’s made by Madhouse, and there’s plenty of violence. Comparable to something like Monster in a way.

Character designs are quality.

2. Seitokai Yakuindomo

This is the kind of anime you don’t watch when parents or family are in the room. Or when you’re out in public unless you give no f*cks.

The main characters are:

Shino Amakusa.
Shichijou Aria.
Tsuda.
Suzu Hagimura.

2 of them are on the sane side of things, while the other 2 are snarky, sarcastic, purposely take things out of context, and have a dirty mind.

They’re constantly making lewd jokes and it only gets more extreme with each season it seems.

Underrated slice of life series without a doubt. Deserves more appreciation (especially with the character chemistry).

3. Slayers

In this classic Shounen/fantasy series you have:

Lina Inverse.
Gourry Gabriev.
Ameila Wil Tesla Seyruun.
Zelgadis Greywords.

They’re personally one of the best groups of 4 in anime history. And they all bring something different to the table.

Lina is a powerful mage with magic rivalling the DBZ universe. She’s stubborn, aggressive in achieving her goals, and confident.

Gourry is the swordsman who sticks with Lina. While the other two are powerful mages with their own set of unique magic.

It’s hard to see chemistry like THIS these days (in groups of 4 in anime). It’s legendary in its own right.

4. Konosuba

Konosuba, or Kono Subarashii is an anime I wasn’t sure I’d like. The comedy can be extreme, but Its become one of my top comedy series.

The main cast is:

Goddess Aqua.
Kazuma Satou.
Megumin.
Darkness Lalatina.

Probably one of the TOP anime characters of all time in groups of 4. They compliment each other so well you won’t forget any of their names or roles.

They’re memorable and reliant on each other in one way or another, especially as far as plot most of the time.

Kazuma in particular is a well written MC and is the pillar of “gender equality” in the anime community. Partly thanks to the anime’s unconventional writing.

5. Fairy Tail

Fairy Tail is a big anime series with endless amounts of episodes, and a big cast of anime characters.

The main group of 4 in this anime series:

Natsu Dragneel.
Erza Scarlet.
Lucy Heartfilia.
Gray Fullbuster.

Just like Konosuba, these 4 Fairy Tail characters are one of the most iconic in anime. Most know them, even if they’re not fans.

Even though not all characters in FT are the most relevant, they are memorable besides the main cast. Which is its strong point.

Fairy Tail is nowhere near as bad as people try to make it out to be. Ratings speak for themselves.

6. Shakugan No Shana

Shakugan No Shana rotates between its characters a lot. So it’s not always something you see when it comes to groups of 4.

That said, the characters are:

Shana.
Yuji Sakai.
Margery Daw.
Wilhelmina Carmel.

Sometimes that changes depending on the season, the arc, and what’s happening. The teamwork between characters in this anime is solid.

It’s classic Shonen but with a female and male lead, and was made back in the mid 2000’s by J.C Staff.

The plot is about demons, humans, the flame haze that destroy demons, and their mission to protect the world’s balance.

7. Naruto

Depending on how you feel, there are different characters you can pick out of Naruto for groups of 4.

For me I’ll go with:

Might Guy.
Tenten.
Rock Lee.
Neiji Hyuga.

Team Guy has one of the best groups of 4 in anime and in Naruto. They’re an energetic set of characters with different sets of talents that aren’t typical..

You obviously have the main team 7 which is Naruto, Sakura, Sasuke, Kakashi…. But Sakura holds it back in the first season of Naruto.

Either way, worthy characters when all is said and done.

8. Hanayamata

Hanayamata is an anime by Madhouse, believe it or not. It’s unusual for them considering their catalog.

It’s a slice of life series in a setting of “cute thing being Yosakoi, a type pf Japanese dance.

The main characters:

Hana Fountainstand.
Naru Sekiya.
Tami Nishimikado.
Yaya Sasame.

A mixture of introverts, extroverts, easy going and “Senpai” type characters.

You can think of the anime like an alternative to Love Live, There’s no fanservice, and it’s completely wholesome and appropriate.

9. K-On

Made by Kyoto Animation, K-On is one of many original anime series that didn’t start from a light novel or manga.

It’s the anime responsible for the Moe genre, given the anime’s influence and originality at the time it first aired.

The main cast:

Yui Hirasawa.
Tsumugi Kotobuki.
Mio Akiyama.
Ritsu Tainaka.

The chemistry between these characters is legendary in the slice of life/comedy community. Later there are 5 characters, but the 4 start it off.

Drinking tea, eating biscuits and cake, playing music together, creating their own band, and enjoying themselves.

That’s the plot basically.

Relevant: The Most Famous Anime Dere Types That Changed The Industry

10. Jujutsu Kaisen

JJK is a solid Shonen series for a lot of reasons. One of them is the solid writing of female and male characters.

The other reason is the chemistry between its 4 main characters, and how they interact and work together.

The main cast is:

Gojo Satoru.
Nobara Kugisaki.
Yuji Itadori.
Megumi Fushigoro.

Megumi’s the introvert, the rest are energetic and a bit much for Megumi at times. But it makes for good comedy.

Easily o e of the best groups of 4 in anime in almost every way imaginable.

11. How To Raise A Boring Girlfriend

Saekano, or How To Raise A Boring Girlfriend is a Harem/Ecchi series you wouldn’t expect to be so good.

It’s a stand out series in the genre.

The main character Tomoya is trying to build a dating sim game, and 3 other girls (main characters) help him out.

Those characters are:

Tomoya Aki.
Utaha Kasumigaoka.
Eriri Spencer.
Megumi Kato.

Each of the girls is a mix of authors, writers, Utaha being a best selling author. And Megumi being an average girl with no current creative passion or talents.

She’s the girl the show is built around in a subtle way which slowly reveals itself.